Orthokine Therapy

Autologous Condition Serum (ACS) and Orthokine Therapy

Orthokine Therapy involves the stimulation of your white blood cells and platelets to produce anti-inflammatory proteins and growth factors. Successfully used in Germany for over ten years, this therapy consists of collecting your blood, incubating it overnight and centrifugation. Typically, this will produce six growth factor-rich serum injections that are stored in a medical grade freezer (<21°C). This is a natural therapy, and nothing is added to your blood. Both cytokines and growth factors are essential in the healing of injuries and in helping the management of arthritis.


Osteoarthritis is considered an inflammatory condition involving pro-inflammatory proteins circulating within the joint, eroding the hyaline cartilage covering the joint surfaces. Laboratory studies have shown that a patient’s blood treated using the orthokine technique produces crucial anti-inflammatory proteins, called IL-1Ra, amongst others. These anti-inflammatory growth factors are then injected into the joint neutralizing the inflammation and restore the normal joint homeostasis. As a result, there is often a reduction in pain and improvement in joint function. Furthermore, there are fewer pro-inflammatory proteins to erode the joint surface and cause osteoarthritis.

Your growth factor rich serum is injected into the joint using sterile technique and under ultrasound guidance. A local anaesthetic is injected into the skin which makes the injection virtually pain-free.

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How does Orthokine/Supakine Therapy Work?

What Orthokine / ACS Therapy does is help your body over-produce chemicals that shift the balance in favour of anti-inflammatory proteins.The most important of these is Interleukin 1 Receptor antagonist (IL-1Ra). It is a ‘protective’ protein that blocks inflammatory proteins in our joints, the effect of which is to provide relief of pain and inflammation.

Am I suitable for this therapy?

Our Podiatrist is best placed to advise you if you are suitable for this therapy. However, due to the autologous nature of this therapy, most people with joint injuries or degenerative diseases would benefit from this treatment. Patients with mild to moderate osteoarthritis tend to have better results than those with advanced states.

The studies suggest a positive response up to 2 years, but if symptoms return further injections can be performed as recommended by your Podiatrist. Clinical evidence suggest that Orthokine/Supakine may also help to maintain a healthy joint and most likely prevent, or at least slow down the degenerative process. Clinical trial results have shown that Cytokine therapy relieves pain and may delay the need for surgery in some patients. As Cytokine therapy is based on using only substances that originate from the body of the patient, the therapies are well tolerated.

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On-site Musculoskeletal ultrasound

At The Foot and Ankle Clinic Sale Practice, Dr. James Ferrie utilises advanced ultrasound imaging onsite, allowing for a comprehensive treatment plan to be established at your initial consultation.

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Ultrasound-guided joint injections

Ultrasound allows for visualising of Musculoskeletal tissue. We can identify the injured tissue in the office without having to wait for an MRI. During treatment, we inject the injured structures and maintain continued needle visualisation of the targeted areas.


What can I expect at my 1st consultation ?

  • Listen to you
  • Accurate diagnosis from previous scans and on-site ultrasound assessment.
  • Physical assessment/biomechanical assessment.
  • Develop a tailor-made comprehensive treatment plan to manage your condition.
  • Discussing your suitability for a regenerative tissue therapy.

Does it hurt?

We do not believe treatments should be painful. Before your injections, it is common for a nerve block to be performed ensuring a pain-free procedure.

What is the success rates of tissue regenerative treatments?

Success rates are high. 80% of patients receive significant relief after treatment. Success will vary depending on the severity of the condition and general health & age. There are some patients who, due to certain health conditions or medical history, will not be suitable for regenerative injections.

What are the risks?

Tissue regenerative procedures have a proven track record when it comes to safety; complications are very uncommon mainly as these procedures utilise your own cells and very fine needles.

There are some inherent risks which are present for any injection, and these include infection and injury to nerve or blood vessel. At The Foot and Ankle Clinic, we use the latest in clinical ultrasound guidance to ensure best practice, and all laboratory work is conducted in a sterile air environment to provide the highest safety standards.

At the Foot and Ankle Clinic our highly qualified team of Podiatrists are all members of the Australian Podiatry Association and offer a combined 50 years’ experience.

Put your feet in our hands! See Dr. Ferrie today at our Sale clinic.